Publications
Identification of small-molecule autophagy activators via GFP-LC3 high-throughput screening and a cargo-based autophagy flux and processing assay
Sven Jonckheere, Joachim Taminau, Jamie Adams, Jef Haerinck, Jordy De Coninck, Jeroen Verstappe, Kato De Clercq, Evelien Peeters, Alexander Gheldof, Eva De Smedt, Vera Goossens, Dominique Audenaert, Aurélie Candi, Matthias Versele, Dominic De Groote, Hanne Verschuere, Marc Stemmler, Thomas Brabletz, Peter Vandenabeele, Andreu Casali, Kyra Campbell, Steven Goossens & Geert Berx
European Journal of Pharmacology 2026
Development and validation of a high-throughput screening pipeline of compound libraries to target EMT
Sven Jonckheere, Joachim Taminau, Jamie Adams, Jef Haerinck, Jordy De Coninck, Jeroen Verstappe, Kato De Clercq, Evelien Peeters, Alexander Gheldof, Eva De Smedt, Vera Goossens, Dominique Audenaert, Aurélie Candi, Matthias Versele, Dominic De Groote, Hanne Verschuere, Marc Stemmler, Thomas Brabletz, Peter Vandenabeele, Andreu Casali, Kyra Campbell, Steven Goossens & Geert Berx
Cell Death & Differentiation 2025
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids
Eva Blondeel, Sam Ernst, Felix De Vuyst, Ákos Diósdi, Cláudio Pinheiro, Diogo Estêvão, Pekka Rappu, Robin Boiy, Sándor Dedeyne, Ligia Craciun, Vera Goossens, Jonas Dehairs, Tânia Cruz, Dominique Audenaert, Wim Ceelen, Michael Linnebacher, Tom Boterberg, Jo Vandesompele, Pieter Mestdagh, Johan Swinnen, Jyrki Heino, Peter Horvath, Maria José Oliveira, An Hendrix, Pieter Demetter & Olivier De Wever
Nat Protoc 2025
Discovery and Characterization of a Selective Inhibitor of Synaptojanin1 5-Phosphatase Activity
Ella Martin, Danaë Giakoumakis, Jone Paesmans, Nicolò Bisi, Andrzej Drozdzecki, Dominique Audenaert, Jurgen Haustraete, Patrik Verstreken, Christian Galicia, Steven Ballet, Wim Versées
ACS Pharmacology & Translational Science 2025
High-throughput screening assay for nitrification inhibitors and the discovery of goitrin as a biological nitrification inhibitor
Fabian Beeckman, Andrzej Drozdzecki, Alexa De Knijf, Dominique Audenaert, Tom Beeckman, Hans Motte
Journal of Microbiological Methods 2025
Small-molecule-induced ERBB4 activation to treat heart failure
Julie M. T. Cools, Bo K. Goovaerts, Eline Feyen, Siel Van den Bogaert, Yile Fu, Céline Civati, Jens Van fraeyenhove, Michiel R. L. Tubeeckx, Jasper Ott, Long Nguyen, Eike M. Wülfers, Benji Van Berlo, Antoine A. F. De Vries, Nele Vandersickel, Daniël A. Pijnappels, Dominique Audenaert, H. Llewelyn Roderick, Hans De Winter, Gilles W. De Keulenaer & Vincent F. M. Segers
Nat Commun 16, 576, 2025
The novel family of Warbicin® compounds inhibits glucose uptake both in yeast and human cells and restrains cancer cell proliferation
Vanthienen W, Fernández-García J, Baietti MF, Claeys E, Van Leemputte F, Nguyen L, Goossens V, Deparis Q, Broekaert D, Vlayen S, Audenaert D, Delforge M, D’Amuri A, Van Zeebroeck G, Leucci E, Fendt S-M and Thevelein JM
Front. Oncol., 22 August 2024
SPL13 controls a root apical meristem phase change by triggering oriented cell divisions
Yang B, Sun Y, Minne M, Ge Y, Yue Q, Goossens V, Mor E, Callebaut B, Bevernaege K, Winne JM, Audenaert D, De Rybel B.
Science, 2024
Drug discovery-based approach identifies new nitrification inhibitors
Beeckman F, Drozdzecki A, De Knijf A, Corrochano-Monsalve M, Bodé S, Blom P, Goeminne G, González-Murua C, Lücker S, Boeckx P, Stevens CV, Audenaert D, Beeckman T, Motte H.
Journal of Environ Management 2023 Nov 15
Structure-function study of a Ca2+-independent metacaspase involved in lateral root emergence
Stael S, Sabljić I, Audenaert D, Andersson T, Tsiatsiani L, Kumpf RP, Vidal-Albalat A, Lindgren C, Vercammen D, Jacques S, Nguyen L, Njo M, Fernández-Fernández ÁD, Beunens T, Timmerman E, Gevaert K, Van Montagu M, Ståhlberg J, Bozhkov PV, Linusson A, Beeckman T, Van Breusegem F.
Genome Biology. 2023 Jan 13;24(1):6
Systematic optimization of Cas12a base editors in wheat and maize using the ITER platform
Gaillochet C, Peña Fernández A, Goossens V, D'Halluin K, Drozdzecki A, Shafie M, Van Duyse J, Van Isterdael G, Gonzalez C, Vermeersch M, De Saeger J, Develtere W, Audenaert D, De Vleesschauwer D, Meulewaeter F, Jacobs TB.
Genome Biology. 2023 Jan 13;24(1):6
How tech-savvy employees make the difference in core facilities: Recognizing core facility expertise with dedicated career tracks: Recognizing core facility expertise with dedicated career tracks
Lippens S, Audenaert D, Botzki A, Derveaux S, Ghesquière B, Goeminne G, Hassanzadeh R, Haustraete J, Impens F, Lamote J, Munck S, Vandamme N, Van Isterdael G, Lein M, Van Minnebruggen G.
EMBO Reports. 2022 Jun 7;23(6):e55094
Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers
Louros N, Ramakers M, Michiels E, Konstantoulea K, Morelli C, Garcia T, Moonen N, D'Haeyer S, Goossens V, Thal DR, Audenaert D, Rousseau F, Schymkowitz J.
Nature Communications. 2022 Mar 15;13(1):1351
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity
Peirsman A, Blondeel E, Ahmed T, Anckaert J, Audenaert D, Boterberg T, Buzas K, Carragher N, Castellani G, Castro F, Dangles-Marie V, Dawson J, De Tullio P, De Vlieghere E, Dedeyne S, Depypere H, Diosdi A, Dmitriev RI, Dolznig H, Fischer S, Gespach C, Goossens V, Heino J, Hendrix A, Horvath P, Kunz-Schughart LA, Maes S, Mangodt C, Mestdagh P, Michlíková S, Oliveira MJ, Pampaloni F, Piccinini F, Pinheiro C, Rahn J, Robbins SM, Siljamäki E, Steigemann P, Sys G, Takayama S, Tesei A, Tulkens J, Van Waeyenberge M, Vandesompele J, Wagemans G, Weindorfer C, Yigit N, Zablowsky N, Zanoni M, Blondeel P, De Wever O.
Nature Methods. 2021 Nov;18(11):1294-1303
Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
Wei P, Demulder M, David P, Eekhout T, Yoshiyama K, Nguyen L, Vercauteren I, Eeckhout D, Galle M, De Jaeger G, Larsen P, Audenaert D, Desnos T, Nussaume L, Loris R, De Veylder L@
(@ Corresponding)
Plant Cell 1361-1380 33 2021
DOI 10.1093/plcell/koab005
The Screening for Novel Inhibitors of Auxin-Induced Ca2+ Signaling.
De Vriese K, Nguyen L, Stael S, Audenaert D, Beeckman T, Vanneste S
Methods Mol Biol 89-98 2213 2021
DOI 10.1007/978-1-0716-0954-5_8
GOLVEN peptide signalling through RGI receptors and MPK6 restricts asymmetric cell division during lateral root initiation.
Fernandez Salina A*, Vangheluwe N*, Xu K, Jourquin J, Alves Neubus Claus L, Morales S, Parizot B, De Gernier H, Yu Q, Drozdzecki A, Maruta T, Hoogewijs K, Vannecke W, Peterson B, Opdenacker D, Madder A, Nimchuk Z, Russinova E, Beeckman T@
(* CoFirst, @ Corresponding)
NAT PLANTS 533-543 6 2020
DOI 10.1038/s41477-020-0645-z
The CEP5 Peptide Promotes Abiotic Stress Tolerance, As Revealed by Quantitative Proteomics, and Attenuates the AUX/IAA Equilibrium in Arabidopsis.
Smith S et al
(@ Corresponding)
MOL CELL PROTEOMICS 1248-1262 19 2020
DOI 10.1074/mcp.RA119.001826
Identification of Novel Inhibitors of Auxin-Induced Ca(2+) Signaling via a Plant-Based Chemical Screen.
De Vriese K, Himschoot E, Dunser K, Nguyen L, Drozdzecki A, Costa A, Nowack M, Kleine-vehn J, Audenaert D, Beeckman T, Vanneste S@
(@ Corresponding)
PLANT PHYSIOL 480-496 180 2019
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.
Dejonghe W*, Sharma I*, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva M, Savatin D, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, Yperman K, Madder A, Friml J, Van Damme D, Gevaert K, Haucke V, Savvides S, Winne J, Russinova E@
(* CoFirst, @ Corresponding)
NAT CHEM BIOL 641-649 15 2019